Letrozole is the most effective aromatase inhibitor that reduces the level of estrogen (female hormone) in the blood, which is very effective and is NOT a steroid. It quickly became popular in therapy, pharmacology, sports (bodybuilding and powerlifting) and other industries. Letrozole also became popular due to its wide application in various branches of medicine. The important thing is that letrozole is an effective, safe and reliable drug. It is prescribed for both men and women.
What is Letrozole for bodybuilding
The active ingredient Letrozole causes a good effect, blocking the production of aromatase enzymes. Used by athletes and bodybuilders in Post-Course Therapy (PCT), to maintain muscle mass after completion of the course. Clinically used to eliminate gynecomastia, also prescribed to correct low height and in female oncology. Letrozole blocks estrogen receptors, thereby increasing the percentage of testosterone in the body.
A full description of the drug Letrozole contains clear instructions on how to use the drug. It is important, consider the weighty benefits of the non-steroidal drug. The most reliable and most popular letrozole-containing drug, was Caspov Letrozol – to be precise – Kasra Letrozol, much more significant than similar letrozol drugs. The key feature in anti-estrogenic drugs is the possibility of long-term consolidation of the course results. Even after the end of treatment, accumulated muscle mass is not lost. This makes it the drug of choice among bodybuilders.
In recent years, the use of Letrozole for bodybuilding has increased. This is because it is a powerful aromatase inhibitor that can help prevent the conversion of testosterone to estrogen. As a result, it can help preserve muscle mass and strength during a cutting cycle. Additionally, it can also help boost fat loss.
Letrozole is typically used at a dosage of 2.5 mg per day, although some bodybuilders may use up to 5 mg per day. It is important to note that Letrozole should only be used for short periods of time, as it can cause negative side effects such as hair loss and joint pain.
Professional athletes from the world of bodybuilding and other strength sports who use anabolic steroids to improve the quality of their workouts are faced with the conversion of active steroid substances into estrogens, which leads to malfunctions in the athletes’ bodies. Just to combat these negative aspects from taking steroids, there are drugs from the field of aromatase inhibitors. One of the most effective aromatase inhibitor drugs is considered to be Letrozole.
Pharmacological effects of the drug
Antitumor drug, inhibitor of estrogen synthesis. Letrozole has anti-estrogenic effect, selectively inhibits aromatase (enzyme of estrogen synthesis) by a highly specific competitive binding to the subunit of this enzyme – cytochrome P450 heme. It blocks estrogen synthesis in both peripheral and tumor tissues. In postmenopausal women, estrogens are formed mainly with the participation of aromatase enzyme, which converts androgens synthesized in adrenal glands (primarily androstenedione and testosterone) into estrone and estradiol. Daily administration of Letrozole at a daily dose of 0.1-5 mg leads to a decrease in plasma concentrations of estradiol, estrone and estrone sulfate by 75-95% of baseline. Suppression of estrogen synthesis is maintained throughout the treatment period.
When using Letrozole in dose range from 0.1 to 5 mg, no disturbance of steroid hormone synthesis in adrenal glands is observed, ACTH test reveals no disturbance of aldosterone or cortisol synthesis. No additional administration of glucocorticoids and mineralocorticoids is required. Blockade of estrogen biosynthesis does not lead to accumulation of androgens, which are precursors of estrogens. No changes in plasma concentrations of LH and FSH, changes in thyroid function, changes in lipid profile, increased incidence of myocardial infarction and stroke have been noted during treatment with Letrozole. Against the background of Letrozole treatment there is a slight increase in the incidence of osteoporosis (6.9% compared to 5.5% against placebo). However, the incidence of bone fractures in patients receiving Letrozole does not differ from that in healthy people of the same age.
Adjuvant therapy with Letrozole for early-stage breast cancer reduces the risk of recurrence, increases survival without signs of disease for 5 years, and reduces the risk of developing secondary tumors. Prolonged adjuvant therapy with Letrozole reduces the risk of recurrence by 42%. A significant advantage in survival without signs of disease was observed in the letrozole group regardless of lymph node involvement. Letrozole treatment reduces mortality in patients with lymph node involvement by 40%.
Some bodybuilders are using the drug letrozole to try to avoid the side effects of testosterone use. Letrozole is a drug that is used to treat breast cancer in women. It is also sometimes used to help men with low testosterone levels. Some bodybuilders believe that it can help them avoid some of the side effects of testosterone use, such as hair loss and enlarged breasts. However, there is not much evidence to support this claim. Letrozole can cause a number of side effects, including hot flashes, fatigue, and mood changes. It can also increase the risk of developing certain types of cancer.
Letrozol courses in bodybuilding: dosage, composition
According to studies, Letrozol doses of 0.10-0.30 mg. will be able to reduce the level of estrogen in the body by almost 100%. In addition, this drug is an excellent preventive measure to prevent the development of gynecomastia, can increase the concentration of anabolic hormones in the body and prevent arterial hypertension.
If you are on a course of strong anabolic steroids and have decided to fight elevated estradiol with Letrozole, then start taking the drug with the minimum dose. Taking 0.10 mg of the drug every other day would be considered the minimum dose. Such a small dosage is necessary to check the body reaction to Letrozole. Besides we need to keep estrogen presence in our organism. But if such dosage appears to be insufficient and estradiol will still be high, simply increase a dosage to 0,20 mg. through day and if even it appears to be not enough, then increase a dosage to 0,30 mg. through day, but it needs to be done gradually, watching level of an estrogen in blood and listening to the organism. This is the right way of taking Letrozole. Because no coach or sport pharmacologist can calculate the exact dosage of the preparation without knowing the individual characteristics of the sportsman’s organism. The duration of Letrozol intake depends on your experience in sports pharmacology intake and on what preparations you take during the course.
There are a few anabolic steroids that are used by bodybuilders and athletes to help increase muscle mass and strength. These steroids can be very effective, but they also have some serious side effects. One of the most popular anabolic steroids is testosterone. Testosterone is a hormone that is naturally produced in the body. It plays a key role in the development of male sex characteristics and helps to maintain muscle mass and strength.
Testosterone is a banned substance in many sports, including bodybuilding. This is because it can help athletes build muscle mass and strength quickly, which can give them an unfair advantage. There are other legal steroid alternatives available that can help bodybuilders achieve similar results, without the risk of side effects. One of these alternatives is letrozole. Letrozole is a drug that is used to treat breast cancer in women.