Description of Letrozole
Letrozole is a nonsteroidal hormone therapy for neoplasms in women, used during post menopause. It inhibits estrogen synthesis, thus preventing the growth of estrogen-dependent tumors. With the help of the drug the therapy of malignant formations of the mammary glands at an early stage is carried out. Letrozole should be prescribed only by a doctor. Taking the drug is strictly forbidden for pregnant and breastfeeding women. During treatment with Letrozole, it is necessary to refrain from driving and operating complex machinery. Read the detailed instructions carefully.
Letrozole is a nonsteroidal hormonal therapy for neoplasms in women and is used during post menopause. It inhibits the synthesis of estrogen, which prevents the growth of estrogen-dependent tumors. With the help of the drug the therapy of malignant formations of the mammary glands at an early stage is carried out. Letrozole should be prescribed only by a doctor.
Taking the drug is strictly forbidden for pregnant and breastfeeding women. During treatment with Letrozole, it is necessary to refrain from driving and operating complex machinery. Read the detailed instructions carefully.
Overview of the steroid Letrozole
Each Letrozole Pharmland tablet contains the active ingredient letrozole. It belongs to a group of drugs called aromatase inhibitors. Letrozole is used for the hormonal treatment of breast cancer.
The growth of breast cancer is often stimulated by estrogens, which are female sex hormones. Letrozole reduces estrogen by blocking the aromatase enzyme, which is involved in the formation of estrogen. Because of this, this drug can prevent the growth of breast cancer, which needs estrogens. As a consequence, the growth of tumor cells is slowed or stopped and/or their spread to other parts of the body is stopped. Letrozole Farmland is used to treat breast cancer in menopausal women (permanent cessation of menstruation).
This drug is used to prevent the recurrence of cancer. Letrozole Farmland can be used as the main drug 1) before breast cancer surgery if emergency surgery is not acceptable, or 2) as the main drug after breast surgery, or 3) after 5 years of tamoxifen treatment. This drug is also used to prevent the spread of breast cancer to other organs in patients with advanced breast cancer.
Letrozole is rapidly and completely absorbed from the gastrointestinal (GI) tract, with an average bioavailability of 99.9%. Food intake slightly reduces the absorption rate. Mean value of time of maximum letrozole concentration in blood (ТСmax) is 1 hour when letrozole is taken on an empty stomach and 2 hours – when used with food; mean value of maximum concentration (Сmax) is 129±20.3 nmol/l in fasting and 98.7±18.6 nmol/l in food, but letrozole absorption degree (when estimated by area under curve “concentration-time” (AUC)) is not changed. Slight changes in the absorption rate are regarded as having no clinical significance, so letrozole can be taken regardless of food intake.
The binding of letrozole with blood plasma proteins is approximately 60% (predominantly with albumin – 55%). Letrozole concentration in erythrocytes is about 80% of that in blood plasma. The apparent volume of distribution in equilibrium is about 1.87±0.47 l/kg. The equilibrium concentration is reached within 2-6 weeks of daily administration of a daily dose of 2.5 mg. Pharmacokinetics is non-linear. No cumulation during long-term use has been observed. Letrozole is largely metabolized by CYP3A4 and CYP2A6 cytochrome P450 isoenzymes to form pharmacologically inactive carbinol compound. It is excreted mainly by the kidneys as metabolites, to a lesser extent – through the intestine. The terminal elimination half-life (T1/2) is 48 hours.
Overview of the Letrozole drug cycle
The method of use and doses of Letrozole are prescribed solely by the attending physician. The therapy with Letrozole must be carried out under medical supervision. The doses and duration of therapy are determined individually and may vary depending on the nature and severity of the disease. The daily dose of 2.5 mg of Letrozole per day is usually prescribed in the regimen of adjuvant therapy.
In this case, adjuvant and extended adjuvant therapy can last up to 5 years (or until the disease relapses). After standard therapy with tamoxifen, patients should be monitored by a physician and continue therapy with letrozole for 4 years (or until relapse). Patients with metastases should be treated with letrozole until signs of disease progression become evident. When using Letrozole in preoperative preparation the doctor should constantly monitor the patient’s condition. In elderly patients and in case of moderate or mild hepatic impairment the change of letrozole dose is not necessary. Taking into account the risk of osteoporosis development against the background of Letrozole therapy, it is necessary to monitor the state of bone tissue in patients receiving treatment.
If you are considering using the drug Letrozole to treat your breast cancer, it is important to understand what the drug is and how it works. Letrozole is a type of hormone therapy that is used to treat estrogen receptor positive breast cancer. This type of cancer uses estrogen to grow, so blocking the effects of estrogen with this drug can help to stop or slow the growth of the tumor.
There are several potential side effects associated with Letrozole, but most people tolerate it well. The most common side effects are hot flashes, nausea, and fatigue. Some people also experience hair loss, bone pain, and mood changes. It is important to talk to your doctor about any side effects you are experiencing so that they can be addressed promptly.
If you’re looking for a powerful Femara alternative, look no further than Letrozole. This drug is often used during post-cycle therapy to help restore natural testosterone production. Unlike Femara, Letrozole doesn’t seem to cause any estrogenic side effects like breast enlargement or water retention. In fact, many people report feeling better on Letrozole than they did on Femara.
One potential downside to Letrozole is that it can be a little harsh on the liver. As with any drug, it’s important to consult with your doctor before starting treatment. If you have any preexisting liver problems, Letrozole may not be the best choice for you. Overall, Letrozole is an excellent drug for restoring testosterone production and alleviating estrogenic side effects.